N/P Ratio Significantly Influences the Transfection Efficiency and Cytotoxicity of a Polyethylenimine/Chitosan/DNA Complex
نویسندگان
چکیده
منابع مشابه
N/P ratio significantly influences the transfection efficiency and cytotoxicity of a polyethylenimine/chitosan/DNA complex.
For designing a complex vector that has the advantages of both polyethylenimine (PEI) and chitosan for gene delivery, a PEI/chitosan/DNA complex was constructed at various N/P ratios (the ratios of moles of the amine groups of cationic polymers to those of the phosphate ones of DNA) and both the cytotoxicity and the transfection efficiency of the vector were evaluated. The results demonstrated ...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2009
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.32.706